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© 2012 American Society for Nutrition

Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents1,2,3

Karolien Van Puyenbroeck,
Niel Hens,
Samuel Coenen,
Barbara Michiels,
Caroline Beunckens,
Geert Molenberghs,
Paul Van Royen, and
Veronique Verhoeven

+ Author Affiliations

1From the Department of Primary and Interdisciplinary Care (KVP, SC, BM, PVR, and VV), the Vaccine & Infectious Disease Institute–WHO Collaborating Centre (NH and SC), and the Centre for Health Economics Research and Modeling Infectious Diseases (NH), University of Antwerp, Antwerp, Belgium, and I-BioStat, Hasselt University and Katholieke Universiteit Leuven, Diepenbeek, Belgium (NH, CB, and GM).


+ Author Notes

↵2 Supported by Yakult Honsha Co Ltd.


↵3 Address correspondence to K Van Puyenbroeck, Department of Primary and Interdisciplinary Care, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. E-mail: karolien.vanpuyenbroeck@ua.ac.be.



Abstract

Background: Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination.

Objective: We assessed whether an intervention with Lactobacillus casei Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination.

Design: Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged ≥65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained ≥6.5 × 109 live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination.

Results: Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168, 1.2887). No significant difference regarding the influenza-vaccination immune response was shown.

Conclusion: The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277.


Footnotes
Received September 13, 2011.
Accepted February 2, 2012.


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